I would like to start a thread based purely on tramadol and mainly its and often overlooked ability to release 5-ht along with other neurochemical actions like: norepinephhrine re-uptake, mu(opioid) receptor agonism,NMDA antagonism, acts as a agonist nad antgonist at various 5-ht rector types and subtypes, a nicotinic acetylcholine receptor antagonist.. THE real issue is that there is massive demand and a trend in
chemicalneuromechanicanical prefference towards monoamine releasers, more specifically serotonin releasing agents(SRAs). FROM MDMA itself to the" beta-ketone revolution" that the RC community has bear witness to, seems soely on the revision of substituted amphetamines(MDXX/Xamphetamine) and to a leser extent phenethylamines(basic) to their cathinone(beta-ketone) equivalents, in search of legaland quasi legalempathogen/entactogents/serenics(anti-aggressive agents). Wich usually if not always base their action on the release of monoamines mainly serotonin. YES there have been many tryptamines (AMT for example) and odd morpholine(not morphine) derived chems that posess this sought after mechanism of action(MOA). But all along shuned by opiate addicts due to low potency, scalded upon by recreational users for lowered seazure threshold, there was Tramadol, wich does have a cult folowing for people that find its subtle( and sometimes not so subtle) effect of (serenic) euphoria, social lubrication, motivation, mild analgesic action, off-lable RLS cure, potent anti-depressant(and fast acting)!!, and with a small dose of a benzodiazepine or high dose valerian( DO NOT COMBINE WITH KAVA) will erradicate the seizure worry at even maximum prescribed dosage, unless you are prone in wich you are usually already on a anti-convulsant in the first place, can provide a euphoria that many either dont get due to metabolism(CYP enzyme deficiency) or dont get due to high stimulant tolerance/opioid tolerance. But if you are one of the few that find tramadol and its unique mechanisms of action( for a unscheduled RX) a very nice and sometimes highly synergistic chem i would love to here comments questions, and horror stories concerning this compound. keep in mind that there are far more potent 5-ht releasers, but til this day i have yet to find a forgiving one used chronically (several years) that continues to do what it does, and contrary to what docs will tell you it is addictive and has a terrible withdrawl( think mild opiate/strong anti-depressant withdrawl) thus cycling is in order for dosing to minimize tolereance issues, that would arrise with daily dosages acceding 100mgs.